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KMID : 0371420221020020065
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Annals of Surgical Treatment and Research
2022 Volume.102 No. 2 p.65 ~ p.72
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In vivo study for the hemostatic efficacy and foreign body reaction of a new powder-type polysaccharide hemostatic agent
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Byun Yoon-Hyeong
Kim Eun-Jin
Lee A-Reum
Suh Young-Ah
Sohn Hee-Ju
Lee Jung-Min
Kang Jae-Seung
Choi Yoo-Jin
Han Young-Min
Kim Hong-Beom
Kwon Woo-Il
Jang Jin-Young
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Abstract
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Purpose: Various hemostatic agents have been introduced in therapy as postoperative bleeding is a poor prognostic factor for postoperative outcomes. These products can be divided into those that directly promote the hemostatic cascade and those that physically form a barrier by absorbing blood. The latter, powder-type hemostatic agents have the advantages of being inexpensive and more absorbable with less foreign body reactions (FBRs) and are applicable to a relatively wide area. This study was conducted to verify the safety and efficacy of a newly invented polysaccharide product (OOZFIX, Theracion Biomedical), which improves blood absorption and hemostatic effects.
Methods: Two separate animal experiments were performed. The first evaluated FBRs histologically at 3 days, 2 weeks, and 4 weeks, after implantation of OOZFIX in rats, and the second compared hemostatic performance of OOZFIX and Arista AH (Bard) in the porcine liver punch biopsy model.
Results: We found minimal FBRs in the 3-day group and no reactions in both the 2-week and 4-week groups after implantation of hemostatic agents. The time to hemostasis of OOZFIX was not significantly different from that of Arista AH (median [interquartile range]: 9 [6?10] minutes vs. 8 [6?10] minutes, respectively; P = 0.522). When comparing the serial bleeding grade tendency, there was no statistical difference between OOZFIX and Arista AH (P = 0.656).
Conclusion: OOZFIX caused a minimal FBR that disappeared within 2 weeks in vivo, and its hemostatic performance was comparable with that of an existing agent, Arista AH. Further clinical studies are required in the future.
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KEYWORD
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Animal experiment, Foreign body reaction, Hemostatics, Polysaccharides, Porcine liver punch biopsy model
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